You must read this part to understand our process. If you decide to order RxReport™, you will be required to give informed consent and make certain important choices regarding your test.
Which Genes are tested?
At Personalized Prescribing Inc., we test for more than 50 genes that include CYP2D6, CYP2C19, CYP2C9, TPMT, VKORC1, SLCO1B1, UGT1A1, ABCB11, DPYD, Factor F5 Leiden etc.
Which Drugs are covered by these Genes?
The genes listed above are associated with varied response in several drugs currently on the market. At Personalized Prescribing, we only provide recommendations for the drugs that have been clinically validated at the highest level by independent consortia on Pharmacogenomics.
The drugs that we provide recommendations for can be found on our searchable Drug List.
The Difference between Genetic Information and Drug Recommendations
There is a big difference between the terms “genetic information” and “drug recommendations”, particularly for the use of this pharmacogenomic test.
“Genetic Information” refers to the actual genetic code found in DNA. We all have the same genes, but it is our unique variations in these genes that make us different. For the purpose of this pharmacogenomic test, the term “genetic information” will refer to the unique genetic variations as determined by our laboratory from your DNA sample. These genetic variations are written as either a single mutation (ex. 1029A>C) or as a combination of mutations within the same gene, also called a haplotype (ex. *17). A haplotype is a combination of mutations within a gene.
“Drug Recommendations”, for the purpose of this pharmacogenomic test will refer to the clinically validated recommendation provided by Clinical Pharmacogenomics Implementation Consortia (CPIC) or Dutch Pharmacogenomic Working Group (DPWG) for each particular drug covered by this test. Your genetic information (as defined above) is used to determine which drug recommendation to provide in your test results. Drug recommendations are not considered genetic information, as they do not contain any reference to your unique genetic code. An example of a drug recommendation would be,“Elevated CYP2C19 and normal CYP2D6 enzyme activity. Consider alternative drug NOT metabolized by CYP2C19. If a tricyclic is warranted, utilize therapeutic drug monitoring to guide dose adjustments”.
Subscribers taking the RxReport™ are entitled to receive any information about their health that is produced by the test (Healthcare Consent Act). However, RxReport™ subscribers must understand the consequences of knowledge of any or all parts of their health information. Subscribers may request access to some or all their information; in that case they are responsible for any and all consequences stemming from the information they obtain. Because of this, please read the next part of our disclosures and disclaimers very carefully.
Important Disclaimers for Anyone Considering Taking this Pharmacogenomic Test:
Pharmacogenomic testing is extremely accurate, and our laboratory is CLIA certified (the highest level of accreditation for laboratories under the FDA). However, like all testing there is a small possibility of delay or error.
To the best of our ability, Personalized Prescribing Inc. will ensure that any and every system that we maintain control over remains completely secure. However, no system is 100% secure. We will never sell, share, or disclose your personal information, health information, or genetic information to anybody without your consent. However, it is extremely unlikely yet possible that your information could be taken from our system without our permission (i.e. hacked).
Knowledge of Your Genetic Information
You must be aware that if you know your genetic information, you may be asked to disclose that information in a health or medical questionnaire.
Although the genetic information produced in this Pharmacogenomic test does not confer any type of risk of developing a certain disease currently, there is a possibility that new scientific discoveries of the future could determine an association with the genetic information produced in this test and a risk of developing a certain disease.
For example, if you know your genetic information and you decide to apply for life insurance, you may be required to disclose your genetic information at some point during the application process.
Be aware that in disclosing your genetic information to another party, you may be at risk of discrimination by that party or by another party that may see your genetic information as a result.
Consult Your Doctor
Never make any changes to your medication without first consulting your doctor. There may be factors other than your genetics that affect your response to medication. Please share the results of this Pharmacogenomic test with your prescribing physician and or your pharmacist. You may request that the report is not shared with you, but only shared with your healthcare professional.